Fats, proteins and carbohydrates are the main sources of energy in human nutrition. The relationship between these three has been the subject of much debate in nutritional science over the years. Carbohydrates were important to our ancestors because many carbohydrate-rich foods were easy to store without refrigeration compared to protein-rich or high-fat foods such as… Continue reading
Month: April 2020
The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of human adenovirus (AdV), a virus that can kill immunosuppressed patients. Cell biological analyses, genetics and chemical interference demonstrate that one of five AdV membrane proteins, the E3-19K glycoprotein specifically triggers the unfolded protein response… Continue reading